Multiscale Tissue Engineering Laboratory

We aim to implement bio-inspired principles through AI and apply them to tissue engineering and regenerative medicine.

Our Research Contact Us

Research

Our lab develops AI-driven, bio-inspired platforms that bridge nanomaterials, peptides, and living systems for tissue regeneration and therapeutic applications.

AI-based de novo peptide and protein design

AI-based de novo design

We design peptides and proteins from scratch using structure prediction and generative models. By learning from natural sequences and structures, we create novel biomolecules with tailored functions for tissue engineering and regenerative medicine.

Cascade nanozyme and reactive oxygen species regulation

Cascade nanozyme

We engineer multi-enzyme-mimetic nanoparticles that perform cascaded reactions, including ROS conversion and oxygen generation. These nanozymes modulate the tissue microenvironment, alleviate oxidative stress, and support cell survival in damaged tissues.

Biomimetic functional materials and peptide-based biomaterials

Biomimetic functional materials

We develop self-assembling peptides, peptide-polymer hybrids, and nano-biohybrid materials that mimic extracellular matrix and cellular interfaces. These biomimetic materials provide instructive cues for adhesion, differentiation, and tissue formation.

Tissue engineering and regenerative medicine applications

Tissue engineering applications

We integrate AI-designed biomolecules, cascade nanozymes, and biomimetic materials into 3D constructs and in vivo models. Our goal is to restore function in damaged tissues and organs through multiscale strategies spanning molecules, cells, and living systems.

Research Keywords

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People

Su-Hwan Kim

Su-Hwan Kim

Assistant Professor, School of Integrative Engineering
Chung-Ang University

Postdoctoral Fellow, Harvard University
Ph.D. in Seoul National University
B.S. in Korea University
Email: suhwankim@cau.ac.kr

G Google Scholar in LinkedIn

Graduate Students

MS/PhD

Sumi Choi

Master-Ph.D. Integrated Program
School of Integrative Engineering

B.S.

PhD

Minjeong Kim

Ph.D. Program
School of Integrative Engineering

M.S.

PhD

Minjin Kim

Ph.D. Program
School of Integrative Engineering

M.S.

MS

Geonho Bing

Master Program
School of Integrative Engineering

B.S.

MS/PhD

Ibrahim Sofiyullaha

Master-Ph.D. Integrated Program
School of Integrative Engineering

B.S.

Alumni +

Graduate Students

  • Jeongmin Han, 2022-2024, Master Degree
  • Jinwoo Hong, 2022-2024, Master Degree; Current Address: Prestige Biopharma IDC
  • Minjeong Kim, 2024-2026, Master Degree; Current Address: Ph.D. Student in Chung-Ang University
  • Minjin Kim, 2024-2026, Master Degree; Current Address: Ph.D. Student in Chung-Ang University

Undergraduate Students

  • Eunhye Yun, 2021-2022; Current Address: Master Program in UNIST
  • Ayeon Shim, 2021-2022
  • Kyungjin Kim, 2021-2023
  • Byunghoon Choi, 2022-2024
  • Taehee Lee, 2023-2024
  • Donghee Lee, 2023-2024

Publications

Selected peer-reviewed publications from the Multiscale Tissue Engineering Laboratory. * Corresponding author. # Equal contribution.

Selected Peer-Reviewed Publications

All Publications by Year +
2026 (8) +

  1. Geonho Bing#, Sumi Choi#, Sang Jin Lee, Su-Hwan Kim*

    Sponge-Derived Spicules as Mechanotransductive and Immunomodulatory Platforms in Dermatological Therapeutics

    Biotechnology and Bioprocess Engineering, 2026

  2. Sumi Choi, Minjeong Kim, Sang Jin Lee, Su-Hwan Kim*

    Immunomodulatory Nanozymes as Programmable Redox-Immune Set-Point Regulators

    Small, 2026

  3. Chao Liang, Zhenzhen Wu, Ziqi Huang, Siyuan Chen, Feiming Li, Yong-Dae Kwon, Donghyun Lee, Sang-Hyun An, Sumi Choi, Su-Hwan Kim, Sang Jin Lee

    Fully and Spontaneously Degradable Carboxymethyl Chitosan/Oxidized Hyaluronic Acid-Based Membrane Promoting Three-Dimensional Tissue Organogenesis In Vitro and In Vivo

    International Journal of Biological Macromolecules, 2026

  4. Bo Kyeong Kim, Yeongjun Park, Nohseong Park, Giwon Lee, Taek Lee, Su-Hwan Kim*, Hah Young Yoo*, Chulhwan Park*

    Techno-Economic Feasibility Assessment of Integrated Microalgal Biorefinery for Coproducing Biofuel and High-Value Chemicals

    Bioresource Technology, 2026

  5. Jeongmok Yang, Hyeok Ki Kwon, Jong-Min Oh, Sang-Mo Koo, Younghun Kim, Su-Hwan Kim*, Giwon Lee*, Chulhwan Park*

    Evaluation of Ingredient Transparency in Chemical Products and Its Influence on Consumer Trust and Safety Perception

    Korean Journal of Chemical Engineering, 2026

  6. Sumi Choi#, Jeong Hyun Heo#, Ye-Seul Kim#, Jinwoo Hong#, Sieun Lee, Tae-Gyeong Oh, Suhyun Park, Minsu Gu, Seung-Woo Cho*, Yoonhee Jin*, and Su-Hwan Kim*

    Engineering Multi-Functional Enzyme-Mimetic Polyphenol-Catalase Complex for Reversing Hypoxia and Redox Homeostasis in Vascular and Muscular Regeneration

    ACS Nano, 2026. Front Cover

    ACS Nano front cover

  7. Sumi Choi#, Minjin Kim#, Minjeong Kim, Sang Jin Lee, and Su-Hwan Kim*

    Tailoring Carbon-Based Nanozymes without Metal Cofactors: Design Principles and Applications across Therapeutics and Sensing

    Colloids and Surfaces B: Biointerfaces, 2026

  8. Junghyeon Ko, Hyeon-Jin Kim, Jeong-Uk Kim, Seh Ri Oh, Tae Hoon Kang, Junghwan Byun, Uk-Jae Lee, Minglin Ma, Su-Hwan Kim, Byung-Gee Kim, and Nathaniel S. Hwang*

    Light-Responsive Enzyme-Loaded Nanoparticles for Tunable Adhesion and Mechanical Wound Contraction

    Advanced Functional Materials, 2026

2025 (5) +

  1. Su-Hwan Kim*

    Lentiviral Surface Engineering via Tris(2-Carboxyethyl)Phosphine-Mediated HEK-293T Cell Modification

    Biotechnology and Bioprocess Engineering, 2025

  2. Sumi Choi, Minjeong Kim, Minjin Kim, and Su-Hwan Kim*

    Advances in Oxygenation Nanozyme for Overcoming Diabetic Ulcer

    Biomaterials Science, 2025

  3. Su-Bin Park, Junghyeon Ko, Jeong-Uk Kim, Suwan Jeon, Ye-Sol Kim, Hyeon-Jin Kim, Young-Hyeon An, Su-Hwan Kim, Nathaniel S. Hwang*

    Transdermal Insulin Delivery for Type 1 Diabetes Using Reverse Electrodialysis and Ionic Liquid Technology Based on a Size-Dependent Protein Delivery Study

    ACS Applied Nano Materials, 2025

  4. Sumi Choi#, Hyungrok Choi#, Jin Woong Chung, Su-Hwan Kim*

    Injectable Endoplasmin-Loaded Lipid Nanoparticles-Hydrogel Composite for Cartilage Regeneration

    Tissue Engineering and Regenerative Medicine, 2025

  5. Sang Jin Lee, Zhenzhen Wu, Mengyu Huang, Chao Liang, Ziqi Huang, Chen Siyuan, Vidhyashree Rajasekar, Mohamed Mahmoud Abdalla, Haram Nah, Dong Nyoung Heo, Il Keun Kwon, Min-Jai Cho, Seong Jun Kim, Seil Sohn, Su-Hwan Kim, Ryohichi Sugimura, Cynthia Kar Yung Yiu

    Crosslinker-Free In Situ Hydrogel Induces Self-Aggregation of Human Dental Pulp Stem Cells with Enhanced Antibacterial Activity

    Materials Today Bio, 2025

2024 (4) +

  1. Sujin Lee, Seohyeon Kim, Suhyun Park, Dayeong Gang, Su-Hwan Kim*, Hyo-Jin Ahn*, Minsu Gu*

    Enhanced Photocatalytic Kinetics of Hybrid TiO₂ Photocatalysts Sheathed with Polydopamine Toward Efficient H₂O₂ Production

    ACS Applied Energy Materials, 2024

  2. Sumi Choi#, Jung Hun Kim#, Tae Hoon Kang, Young-Hyeon An, Sang Jin Lee, Nathaniel S. Hwang*, Su-Hwan Kim*

    Biomimetic Marine Sponge-Derived Spicules Microparticle-Mediated Biomineralization and YAP/TAZ Pathway for Bone Regeneration In Vivo

    Biomaterials Research, 2024

  3. Jeongmin Han, Sumi Choi, Jinwoo Hong, Dayeong Gang, Seunghoon Lee, Kwangsoo Shin, Junghyeon Ko, Jeong-Uk Kim, Nathaniel S. Hwang, Young-Hyeon An, Minsu Gu*, Su-Hwan Kim*

    Superoxide Dismutase-Mimetic Polyphenol-Based Carbon Dots for Multimodal Bioimaging and Treatment of Atopic Dermatitis

    ACS Applied Materials & Interfaces, 2024. Supplementary Cover

    ACS Applied Materials & Interfaces Supplementary Cover

  4. Beom-Seok Kim, Jeong-Uk Kim, Jaewoo Lee, Kyung Min Ryu, Su-Hwan Kim, Nathaniel S. Hwang

    Decellularized Brain Extracellular Matrix Based NGF-Releasing Cryogel for Brain Tissue Engineering in Traumatic Brain Injury

    Journal of Controlled Release, 2024

2023 (2) +

  1. Jeongmin Han#, Jinwoo Hong#, Hyojun Lee, Sumi Choi, Kwangsoo Shin, Minsu Gu, and Su-Hwan Kim*

    Advances in Polyphenol-Based Carbon Dots for Biomedical Engineering Applications

    European Polymer Journal, 2023

  2. Su-Hwan Kim#, Kwangsoo Shin#, Byung-Gee Kim, Nathaniel Hwang, Taeghwan Hyeon

    Dual Action of Tyrosinase-Mesoporous Silica Nanoparticle Complex for Synergistic Tissue Adhesion

    Chemical Communications, 2023

2022 (4) +

  1. Wooil Kim, Yura Jeong, Sanggeun Back, Su-Hwan Kim, Junehyung Kim

    Decolorization of Textile Dye by Spore Surface Displayed Small Laccase for the Enhanced Thermal Stability and Robust Repeated Reaction

    Biotechnology and Bioprocess Engineering, 2022

  2. Herdeline Ann M. Ardoña, Kevin Shani, John F. Zimmerman, Su-Hwan Kim, Feyisayo Eweje, Dimitrios Bitounis, Dorsa Parviz, Evan Casalino, Michael Strano, Philip Demokritou, Kevin Kit Parker

    Differential Modulation of Endothelial Cytoplasmic Protrusions after Exposure to Graphene-Family Nanomaterials

    NanoImpact, 26, 2022

  3. Uk-Jae Lee#, Junghyeon Ko#, Su-Hwan Kim#, Pyung-Gang Lee, Young-Hyeon An, Hyungdon Yun, Dillon T. Flood, Philip E. Dawson, Nathaniel S. Hwang*, Byung-Gee Kim*

    Light-Triggered In Situ Biosynthesis of Artificial Melanin for Skin Protection

    Advanced Science, 9(7), 2022. Inside Back Cover; Featured in BRIC

    Advanced Science Inside Back Cover

  4. Sumi Choi, Hyerin Ahn, Su-Hwan Kim*

    Tyrosinase-Mediated Hydrogel Crosslinking for Tissue Engineering

    Journal of Applied Polymer Science, 139(14), 2022

2021 (3) +

  1. Young-Hyeon An, Su-Hwan Kim*

    Facile Fabrication of Three-Dimensional Hydrogel Film with Complex Tissue Morphology

    Bioengineering, 8(11), 164, 2021

  2. Young-Hyeon An, Jin-A Kim, Hyun-Gu Yim, Woo-Jung Han, Yong-Beom Park, Hyun Jin Park, Man Young Kim, Jaewon Jang, Racheal H. Koh, Su-Hwan Kim, Nathaniel S. Hwang, Chul-Won Ha

    Meniscus Regeneration with Injectable Pluronic/PMMA-Reinforced Fibrin Hydrogels in a Rabbit Segmental Meniscectomy Model

    Journal of Tissue Engineering, 12, 2021

  3. Jin-A Kim, Young-Hyeon An, Hyun-Gu Yim, Woo-Jung Han, Yong-Beom Park, Hyun Jin Park, Man Young Kim, Jaewon Jang, Racheal H. Koh, Su-Hwan Kim, Nathaniel S. Hwang, Chul-Won Ha

    Injectable Fibrin/Polyethylene Oxide Semi-IPN Hydrogel for a Segmental Meniscal Defect Regeneration

    The American Journal of Sports Medicine, 49(6), 1538-1550, 2021

2020 (5) +

  1. Beom Seok Kim*, Su-Hwan Kim*, Kyung Min Kim, Young-Hyeon An, Kyung Ha So, Byung-Gee Kim, Nathaniel S. Hwang

    Enzyme-Mediated One-Pot Synthesis of Hydrogel with the Polyphenol Cross-Linker for Skin Regeneration

    Materials Today Bio, 8, 100079, 2020

  2. Yin Ji Jin, Rachel H. Koh, Su-Hwan Kim, Kyung Min Kim, G. Kate Park, Nathaniel S. Hwang

    Injectable Anti-Inflammatory Hyaluronic Acid Hydrogel for Osteoarthritic Cartilage Repair

    Materials Science and Engineering: C, 115, 111096, 2020

  3. Young-Hyeon An, Joon Lee, Dong Uk Son, Dong Hyeon Kang, Mihn Jeong Park, Kyoung Won Cho, Semin Kim, Su-Hwan Kim, Junghyeon Ko, Myoung-Hoon Jang, Jae Young Lee, Dae-Hyeong Kim, Nathaniel S. Hwang

    Facilitated Transdermal Drug Delivery Using Nanocarriers-Embedded Electroconductive Hydrogel Coupled with Reverse Electrodialysis-Driven Iontophoresis

    ACS Nano, 14(4), 4523-4535, 2020

  4. Young-Hyeon An, Mihn Jeong Park, Joon Lee, Junghyeon Ko, Su-Hwan Kim, Dong Hyeon Kang, Nathaniel S. Hwang

    Recent Advances in the Transdermal Delivery of Protein Therapeutics with a Combinatorial System of Chemical Adjuvants and Physical Penetration Enhancements

    Advanced Therapeutics, 3(2), 1900116, 2020

  5. Su-Hwan Kim#, Kyungmin Kim#, Beom Seok Kim, Young-Hyeon An, Uk-Jae Lee, Sang-Hyuk Lee, Seunghyun L. Kim, Byung-Gee Kim, Nathaniel S. Hwang

    Fabrication of Polyphenol-Incorporated Anti-Inflammatory Hydrogel via High-Affinity Enzymatic Crosslinking for Wet Tissue Adhesion

    Biomaterials, 242, 119905, 2020. Featured in BRIC

2019 (3) +

  1. Young Hwan Choi*, Su-Hwan Kim*, In-Seon Kim, KyungMin Kim, Seong Keun Kwon, Nathaniel S. Hwang

    Gelatin-Based Micro-Hydrogel Carrying Genetically Engineered Human Endothelial Cells for Neovascularization

    Acta Biomaterialia, 95, 285-296, 2019

  2. Su-Hwan Kim, Seung Jung Yu, Inseon Kim, Jaehoon Choi, Young Hwan Choi, Sung Gap Im, Nathaniel S. Hwang

    A Biofunctionalized Viral Delivery Patch for Spatially Defined Transfection

    Chemical Communications, 55(16), 2317-2320, 2019

  3. G. Kate Park, Su-Hwan Kim, Kyungmin Kim, Priyanka Das, Byung-Gee Kim, Satoshi Kashiwagi, Hak Soo Choi, Nathaniel S. Hwang

    Dual-Channel Fluorescence Imaging of Hydrogel Degradation and Tissue Regeneration in the Brain

    Theranostics, 9(15), 4255, 2019

2018 (1) +

  1. Su-Hwan Kim*, Sang-Hyuk Lee*, Ju-Eun Lee, Sung Jun Park, Kyungmin Kim, In Seon Kim, Yoon-Sik Lee, Nathaniel S. Hwang, Byung-Gee Kim

    Tissue Adhesive, Rapid Forming, and Sprayable ECM Hydrogel via Recombinant Tyrosinase Crosslinking

    Biomaterials, 178, 401-412, 2018

2017 (5) +

  1. Su-Hwan Kim, Young-Hyeon Ahn, Hwan D. Kim, Kyungmin Kim, Sang-Hyuk Lee, Hyun-Gu Yim, Byung-Gee Kim, Nathaniel S. Hwang

    Enzyme-Mediated Tissue Adhesive Hydrogels for Meniscus Repair

    International Journal of Biological Macromolecules, 110, 479-487, 2017

  2. Min-Eui Han, Byung Jae Kang, Su-Hwan Kim, Hwan D. Kim, Nathaniel S. Hwang

    Gelatin-Based Extracellular Matrix Cryogels for Cartilage Tissue Engineering

    Journal of Industrial and Engineering Chemistry, 45, 421-429, 2017

  3. Su-Hwan Kim*, Myungkyung Noh*, Jiyong Kim*, Ju-Ro Lee, Gun-Jae Jeong, Jeong-Kee Yoon, Seokyung Kang, Suk Ho Bhang, Hee Hun Yoon, Jong-Chan Lee, Nathaniel S. Hwang, Byung-Soo Kim

    Graphene Oxide Reinforced Hydrogels for Osteogenic Differentiation of Human Adipose-Derived Stem Cells

    RSC Advances, 7, 20779-20788, 2017

  4. Min-Eui Han, Su-Hwan Kim, Hwan D. Kim, Hyun-Gu Yim, Sidi Bencherif, Tae-Il Kim, Nathaniel S. Hwang

    Extracellular Matrix-Based Cryogels for Cartilage Tissue Engineering

    International Journal of Biological Macromolecules, 93, 1410-1419, 2017

  5. Young-Hyeon An, Seung Jung Yu, In Seon Kim, Su-Hwan Kim, Jeong-Mi Moon, Seunghyun L. Kim, Young Hwan Choi, Joon Sig Choi, Sung Gap Im, Kyung Eun Lee, Nathaniel S. Hwang

    Hydrogel Functionalized Janus Membrane for Skin Regeneration

    Advanced Healthcare Materials, 6(5), 1600795, 2017

2015 and Earlier (3) +

  1. Su-Hwan Kim*, Hak Rae Lee*, Seung Jung Yu, Min-Eui Han, Doh Young Lee, Soo Yeon Kim, Hee-Jin Ahn, Mi-Jung Han, Tae-Ik Lee, Taek-Soo Kim, Seong Keun Kwon, Sung Gap Im, Nathaniel S. Hwang

    Hydrogel-Laden Paper Scaffold System for Origami-Based Tissue Engineering

    Proceedings of the National Academy of Sciences of the United States of America, 112, 15426-15431, 2015. Featured in BRIC and Nature Materials

  2. Hojae Bae, Amir F. Ahari, Hyeongho Shin, Jason W. Nichol, Che B. Hutson, Mhdokht Masaeli, Su-Hwan Kim, Hugh Aubin, Seda Yamanlar, Ali Khademhosseini

    Cell-Laden Microengineered Pullulan Methacrylate Hydrogels Promote Cell Proliferation and 3D Cluster Formation

    Soft Matter, 7(5), 1903-1911, 2011

  3. Kwang Ho Lee, Da Yoon No, Su-Hwan Kim, Ji Hee Ryoo, Sau Fung Wong, Sang-Hoon Lee

    Diffusion-Mediated In Situ Alginate Encapsulation of Cell Spheroids Using Microscale Concave Well and Nanoporous Membrane

    Lab on a Chip, 11(6), 1168-1173, 2011

News

Latest updates from the Multiscale Tissue Engineering Laboratory.

All News by Year +

Contact

We welcome collaborations and inquiries from students, researchers, and industry partners.

Address

Multiscale Tissue Engineering Laboratory
School of Integrative Engineering
Chung-Ang University
Seoul, Republic of Korea

Email

suhwankim@cau.ac.kr

Collaboration

We welcome inquiries regarding student positions, research collaborations, and industrial partnerships.